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KMID : 0829220050290020049
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Korean Journal of Oral and Maxillofacial Pathology
2005 Volume.29 No. 2 p.49 ~ p.59
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Expression of p16 in oral squamous cell carcinoma and its relation to PCNA index and clinicopathologic factors
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Lim Ji-Jun
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Abstract
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The p16 gene encodes an inhibitor of the cyclin-dependent kinase, which inactivates cyclin-dependent kinase and controls the cell cycle progression. The loss of p16 expression or overexpression has been reported in many kinds of tumors. Both p16 and PCNA regulates cell cycle progression at the G1/S checkpoint. Although many researches about the p16 expression in oral cancer have been carried out, there are few studies about the correlation between p16 expression and proliferation of oral cancer cells. The object of this study was to evaluate the availability of p16 as early diagnostic factor and prognostic factor through correlation analysis of p16 expression in oral squamous cell carcinoma and its relation to PCNA index and clinicopathologic factors. So we investigated p16 immunohistochemical expression of 83 oral squmaous cell carcinomas, and obtained the results as followed. 18 out of the 83 cases(21.69%) showed p16 positive and 65 samples(78.31%) showed p16 negative. While the mean value of PCNA indices of p16 positive cases was 65.94±18.32, that of PCNA indices at p16 negative ones 54.79±18.39. This difference between them showed statistical significance.(P=0.030) p16 positive group was 12/60(20.0%) of well differentiated tumors and p16 negative group was 6/23(16.1%) of moderately or poorly differentiated tumors. This difference did not show statistical significance.(P=0.372) From the results above, it was suggested p16 expression is related to PCNA index in oral squamous cell carcinomas.
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KEYWORD
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Oral squamous cell carcinomas, p16, PCNA index
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